Minocycline is a tetracycline antibiotic commonly prescribed for moderate to severe acne. It works by reducing inflammation and targeting Propionibacterium acnes, the bacteria responsible for acne. While effective, minocycline is not superior to other treatments and carries risks such as skin pigmentation, dizziness, and liver dysfunction. Extended-release formulations claim fewer side effects but lack significant evidence of improved safety or efficacy. Minocycline should be considered carefully, especially when other first-line treatments fail. Consult your healthcare provider to determine if minocycline is the right option for your acne management.